PPARGC1A and heart failure: Using experimental animal models of heart failure, other authors have reported unchanged or increased myocardial gene and/or protein expression levels of PGC1A and PPARA in rats [49], [50]; however, these results, obtained in rodents in which heart failure was induced after three weeks of aortic banding or by feeding for 17 weeks with high salt diet, are hardly comparable with those obtained in human failing myocardium.