Interestingly, we also found highly significant HF-related increases in gene expression of the novel endo-lysosomal Ca2+ channels TPCN1 and TPCN2, recently identified as endo-lysosomal Ca2+ channels and components of the receptor for NAADP, the most potent intracellular Ca2+ mobiliser known [38], [39]. The gene discussed is TPCN1; the disease is hydrops fetalis.