The key findings of this study on severe sepsis and septic shock patients are: 1- a graded increase in mortality was associated with the graded AKI severity; 2- severity of AKI did not relate to vasopressor dependency index; 3- plasma cytokine (IL-10, IL-6, and MIF) profiles differed according to AKI severity; 4- support by RRT appeared related to different genotyping profile for HLA-DRB genes, with a “protective" effect of the presence of 4 alleles for HLA-DRB. This evidence concerns the gene HLA-DRB1 and Sepsis.