APOA1 and Mental deterioration: Only ApoA1 showed a statistically significant effect on cognitive decline from CDR = 0 to CDR >0 after controlling for the effects of the other apolipoproteins, and also age, sex, years of education, APOEε4 carrier status and CVD risk index (OR = 0.63, 95%CI = 0.48–0.84, P = 0.001).