HPSE and infection: Factors that influence platelet transfusion include non-immunologic factors such as platelet quality, infection, disseminated intravascular coagulation, bone marrow transplantation, and splenomegalia and immunologic factors such as repeated platelet transfusion that causes the production of human leukocyte antigen (HLA)-I and human platelet antigen (HPA) antibodies [15], [16].