TGM2 and Cowden disease: Recently, a new CD serum marker based on TG2 covalently cross-linked to deamidated gliadin peptides, coined “neo-epitope,” was carefully studied by Matthias et al. and data supporting the use of this new assay (AESKULISA CeliCheck New Generation) in CD diagnosis were obtained in a longitudinal study of 2684 eligible subjects demonstrating a sensitivity of 92,31% and a specificity of 82,89%, that were highest when compared to TG2 ELISA test or anti-EMA tests [55].