HBEGF and Insulin resistance: Many of these cytokines also referred to as “adipokines,” including leptin, TNF-α, IL-6, heparin-binding epidermal growth factor (HB-EGF), and vascular endothelial growth factor (VEGF) among others, may play an important role in many diseases by promoting angiogenesis, inflammation, cell proliferation and insulin resistance [12].