INS and neoplasm: Colocalization/coordination between macrophages/adipocytes and other cells of the immune system in white fat tissue leads to a low-grade, chronic inflammation that produces many cytokines able to initiate, promote, and sustain tumour progression either directly [116], or indirectly, by causing (via inhibition of the INSR signaling) insulin resistance, which leads to the activation of protumorigenic pathways (see Figure 1).