Women with a low estrone level were older (72 ± 7.5 versus 69.2 ± 6.7 years; P = 0.016), thinner (27.9 ± 4.6 versus 30 ± 5.4 kg/m2; P = 0.020), and had less hypertension (95% versus 88%; P = 0.036), diabetes (37% versus 62%; P = 0.003), and lower triglyceride (148.9 ± 63.1 versus 178.5 ± 123.8 mg/dL; P = 0.023), glucose (107.5 ± 32.8 versus 137.3 ± 59.5 mg/dL; P = 0.002), and C-reactive protein levels (0.45 ± 0.55 versus 0.70 ± 1.31 mg/dL; P = 0.045). The gene discussed is CRP; the disease is diabetes mellitus.