The most common sarcomas in which VEGF overexpression was detected were malignant fibrous histiocytoma (30%), carcinosarcoma (30%), leiomyosarcoma (25%), and dermatofibrosarcoma (20%) but VEGF overexpression had prognostic value only in patients affected with leiomyosarcoma. The gene discussed is VEGFA; the disease is leiomyosarcoma.