TLR2 and cytomegalovirus infection: In addition to the in vitro findings, there is clinical evidence that implicates TLR2 in the pathogenesis of HCMV infection; liver transplant recipients who carry the homozygous Arg753Gln mutation of TLR2 have a higher incidence of HCMV-related disease that is associated with increased levels of HCMV DNA in the peripheral blood [23].