Further, HCMV modulates the activity of other innate immunity receptors that induce type I IFN secretion, such as retinoic acid-inducible gene I (RIG-I-) like helicases (RLHs); RIG-I is upregulated quickly in the early phase of HCMV infection in fibroblasts [38]. Here, RIGI is linked to cytomegalovirus infection.