Although not discussed in great detail here, RASSF1A can also promote cell death utilizing the autophagic protein, C19ORF5/MAP1S, [27, 33, 61] the Hippo pathway components MST1/2 and possibly Salvador [14, 62], and, in melanoma cells, influence Bcl-2 levels and activate apoptosis signal regulating kinase 1 (ASK-1) [63]. The gene discussed is MAP3K5; the disease is melanoma.