PKC-ε activators, like bryostatin-1, directly enhance cognition (Wang et al. 2008) and limit dementia in mouse models of AD (Hongpaisan et al. 2011) through several mechanisms which may include (1) Ca2+ flux, (2) GABA(A)R-regulated post-synaptic currents, and (3) cholinergic signaling (Van Kolen et al. 2008). Here, PRKCE is linked to Alzheimer disease.