They also found no difference in the interstitial-fluid insulin concentrations during the steady-state of hyperinsulinemic clamp studies in the patients with type 2 diabetes as compared with normal subjects, suggesting that the delivery of insulin is not responsible for the approximately 80 percent lower rate of glucose infusion in the patients with type 2 diabetes compared with that of normal subjects. The gene discussed is INS; the disease is type 2 diabetes mellitus.