In addition, PPARG interactes with another transfaction factor of forkhead box protein O1 (FOXO1, bin 13.4) to regulate the expression of mitochondrial uncoupling protein 2 (UCP2, bin11.4) and beta-3 adrenergic receptor (ADRB3, bin 8.3), all these genes being associated with metabolic disturbances such as obesity and 2DM[39-41]. This evidence concerns the gene ADRB3 and obesity due to melanocortin 4 receptor deficiency.