To probe published human breast cancer databases for evidence of genetic patterns suggestive of phospho-PR-driven (SUMO-deficient) lesions, we first defined unique PR gene signatures comprised of genes whose expression was greater in cells expressing KR relative to cells expressing WT receptors (expression > 1.5 fold in KR versus WT, BH adjusted P < 0.01). The gene discussed is PGR; the disease is breast carcinoma.