ESR1 and neoplasm: We found that higher methylation of RASSF1A was associated with worse time to first recurrence {HR = 1.93, 95% CI (1.02, 3.67), p = 0.045} and worse overall survival {HR = 1.74, 95% CI (1.11, 2.74), p = 0.016} in multivariable models that included age, tumor size, S-phase, ER, and PR (Table 3, Figures 1 and 2).