We found that the expression of highly tumor-specific targets (HER2, EGFR, GLUT1, CAIX, IGF1-R, and MET) is quite dependent on the tumor histology and molecular subtype: ductal cancers and in particular the basal/TN and HER2-driven subtypes express more frequently highly tumor-specific membrane targets than lobular cancers. The gene discussed is IGF1R; the disease is neoplasm.