Moreover, inactivation of RASSF2 may be an early event in tumorigenesis as it is found inactivated in a high proportion of colon adenomas as well as early stages of prostate cancer [13, 17, 24], raising the possibility that loss of function of RASSF2 may be an initiating event in the development of certain tumor types. This evidence concerns the gene RASSF2 and colon adenoma.