The breast cancer susceptibility and Fanconi proteins FANCD1/BRCA2, the partner of BRCA2 (PALB2/FANCN), a helicase associated with BRCA1 (FANCJ/BACH1), and several newly identified components including FAN1, FANCO/RAD51C, and FANCP/SLX4 [13–17] participate in the pathway to respond to and repair DNA damage (for review, see [5]). The gene discussed is BRCA2; the disease is breast carcinoma.