CD4 and infection: In contrast, it would make sense that LTNPs display a pattern of IL-7/IL-7R more like progressors than controllers, because the need for CD4+ cell replenishment would be expected to depend on the level of viral replication—infection and cell—turnover, which is supported by findings from our own lab (unpublished data) These results are compatible with a hypothesis of low viral replication leading to a reduced number of new CD4+ cells becoming infected.