UMOD and chronic kidney disease: The objective of this study was therefore to sequence UMOD exonic, regulatory and conserved regions in several hundred participants of the Framingham Heart Study (FHS) and the Atherosclerosis Risk in Communities Study (ARIC) selected based on extremes of urinary uromodulin concentrations (FHS) and CKD status and UMOD haplotype surrounding the GWAS signal (ARIC).