In contrast, Nrf2-null mice survive to adulthood, but are more susceptible to a variety of insults, including MPTP and rotenone [23], 6-hydroxydopamine [39], kainic acid [40], 3-nitropropionic acid [24], [25], malonate [24], ischemia [22], and experimental autoimmune encephalomyelitis [41]. Here, NFE2L2 is linked to ischemia.