STC1 and heart failure: Moreover, while STC1 inhibits L-type calcium channels in cultured cardiomyocytes [1], an effect that may have a negative impact on myocardial contractility and blood pressure, particularly in the setting of heart failure [38], we observe normal blood pressure in STC1 Tg mice, and unpublished observations from our lab suggest that STC1 Tg mice outlive WT littermates.