Previous data from our lab suggested a role for STC1 in cardiac function, as the expression of STC1 is markedly increased in cardiomyoctes and blood vessels of failing human heart secondary to DCM [1]; whereas, following treatment with left ventricular assist device, STC1 expression is “normalized” [1], suggesting regulation of STC1 by modifiable factors related to ventricular load. Here, STC1 is linked to familial dilated cardiomyopathy.