We also found that Zbed4 interacts with nuclear and cytoplasmic proteins and corroborated these results by co-immunoprecipitating Zbed4 from Y79 retinoblastoma cells with the identified proteins, Scaffold Attachment Factor B1 (SAFB1), Estrogen Receptor alpha (ERα) and cellular Myosin 9 (MYH9). The gene discussed is SAFB; the disease is retinoblastoma.