In addition, they found that CD4(+)CD25(+)CD127(low/−) Tregs suppressed effector T-cell proliferation and also correlated to advanced stage of GC, suggesting that CD4(+)CD25(+)CD127(low/−) can be used as a selective biomarker to enrich human Treg cells and also to perform functional in vitro assays in GC. Here, CD4 is linked to gastric cancer.