TP53 and cancer: As an example of both the amount of available information and the insufficiency of naïve keyword search, the name of the protein p53 occurs in 53,528 PubMed articles, and while a researcher interested specifically in its role in cancer and its interacting partners might try the search “p53 cancer interaction” to narrow down the results, this query still yields 1,777 publications, enough for months of full-time reading [1].