SERPING1 and hereditary angioedema: Three phenotypic variants of HANE have been defined: type I HANE, that is characterized by a quantitative and functional deficiency of C1 inhibitor (80–85% of cases); type II HANE, which is associated with normal C1 inhibitor levels, but low function (15–20% of cases); type III HANE, that includes rare cases, usually female, in which there are no alterations of quantity and functions of C1 inhibitor and the genetic defect in most cases involves the expression of factor XII (Hageman) resulting in increased production of bradykinin [78, 79].