None of these showed any significant evidence of association – including the lead signals from the WTCCC type 1 diabetes study in the HLA region (rs3129941, P = 0.08), or near the INS (rs3842748, P = 0.64) or PTPN22 (rs2476601, P = 0.38) genes. This evidence concerns the gene PTPN22 and type 1 diabetes mellitus.