The TPX2 network is tumor cell-autonomous and conserved across species, its activation is predictive of reduced distant metastasis-free survival (DMFS) in ER-positive patients, and the nine common hub genes in the TPX2 signature (TPX2, BUB1, UBE2C, CDC20, CCNB2, KIF2C, BUB1B, CEP55, CENPA) that were conserved across all five data sets consist primarily of genes involved in microtubule and mitotic spindle function. The gene discussed is UBE2C; the disease is neoplasm.