These findings are consistent with those of Pauls and colleagues, who found that a mAb to α4 used for the treatment of multiple sclerosis and Crohn's disease did not impact infection of atRA-treated CD4+ T cells by several HIV-1 strains, including two with the LDI/V tripeptide binding motif in the V2 region [64]. This evidence concerns the gene CD4 and Crohn disease.