However, saturating concentrations of α4β7 antibodies had no inhibitory effect on infection of all-trans retinoic acid (atRA) stimulated CD4+ T cells from multiple donors by any of the T/F or chronic control viruses, even though most of their gp120 subunits are predicted to bind this integrin pair based on previously identified genetic signatures [35]. The gene discussed is ITIH4; the disease is infection.