Another group of five uORFs associated with diseases have been tested recently [58] using reporter assays; they include gonadal dysgenesis (SRY) [59], Van der Woude syndrome (IRF6) [60], Carney Complex Type 1 (PRKAR1A) [61], Hereditary pancreatitis (SPINK1) [62], and Thalassaemia-β (HBB) [63]. This evidence concerns the gene PRKAR1A and van der Woude syndrome.