Moreover, it is well documented that almost all CAN-genes in core modules from gliomas exhibit critical alterations in the three important pathway, TP53 pathway (TP53), RB1 pathway (RB1 and CDKN2A), and PI3K/PTEN pathway (PIK3R1, PTEN) [17]. The gene discussed is PIK3R1; the disease is central nervous system cancer.