As the PAH group were older (63.3 ± 10.5 versus 48.7 ± 10.1 years; P = 0.001) and had a longer disease duration (18.8 ± 13.5 versus 7.8 ± 7.2 years; P = 0.003) compared with controls, a multivariable model including NT-proBNP, age, disease duration, and sPAPTTE was used and showed that the sPAPTTE was independently associated with the NT-proBNP level (β = 0.05; 95% CI, 0.03 to 0.06; P < 0.001) but not age (P = 0.19) or disease duration (P = 0.38). This evidence concerns the gene NPPB and pulmonary arterial hypertension.