In a case-control study, Mukherjee et al. [20] showed a mean value of NT-proBNP in patients with and without pulmonary arterial hypertension of 3,365 and 347 pg/ml, respectively, with a cut-off value of 395 pg/ml having a sensitivity of 69% and specificity of 100% for identification of SSc-PAH. The gene discussed is NPPB; the disease is pulmonary arterial hypertension.