To identify the genomic region associated with the stress syndrome, the coding regions of porcine orthologs of human malignant hyperthermia (MH) genes RYR1, CACNA1S, CPT2 and RYR2 were sequenced for SNP discovery in the proband’s family (Additional file 1: Table S1). The gene discussed is CACNA1S; the disease is Malignant hyperthermia.