miR-122/-122a, miR-221/222, miR-145, miR-146a, miR-26 (NFκB pathway), miR-199a-3p (mTOR pathway), and miR-26 (MYC pathway) were strongly linked to the development and metastasis of the HCC and also a group of miRNAs were used to identify and classify HCC [127–132], but none of them were used as a CTC marker and tested during a clinical trial. This evidence concerns the gene NFKB1 and hepatocellular carcinoma.