IL2 and coinfection: The previous studies have shown the correlation between the hereditary susceptibility of gene and liver disease, such as SNPs of aldehyde dehydrogenase 2 (ALDH2) and HCC [11], interleukin-2 (IL-2), IFN-γ, IL-10 and the infection of HBV, HCV, or HBV/HCV coinfection [12].