Shen et al. have identified the association of a TLR7 SNP with SLE in 9274 Eastern Asians with a stronger effect in males than female subjects (odds ratio, male versus female = 2.33 (95% CI = 1.64–3.30) versus 1.24 (95% CI = 1.14–1.34); P = 4.1 × 10−4). Here, TLR7 is linked to systemic lupus erythematosus.