HO-1 expression in cirrhotic patients was significantly higher than that in patients with NASH and chronic hepatitis C. The HO-1 mRNA expression was increased in Child-Pugh class C compared to Child-Pugh class A and B. Furthermore, HO-1 mRNA expression in CLD patients was positively correlated with levels of carboxyhemoglobin, serum ferritin, and serum MDA and negatively correlated with level of erythrocyte GSH. The gene discussed is HMOX1; the disease is congenital secretory chloride diarrhea 1.