In the present study IL28B SNP was carefully typed into four distinct cohorts; namely healthy Egyptian subjects, spontaneous resolvers with detectable HCV Abs and undetectable HCV RNA, chronic HCV type 4a patients with F0-F2 fibrosis and a fourth group of ESLD due to HCV type 4a infection (decompensated LC and HCC). This evidence concerns the gene IFNL3 and fibrosis.