In logical terms, the C/C genotype seems to be under-represented among patients with ESLD since carriage of the rs12979860 C/C genotype protects from unfavorable outcomes in chronic viral hepatitis C. In conclusion; in IL-28B rs12979860 C/T polymorphism the T allele appears to be more prevalent in patients with ESLD (LC and HCC). The gene discussed is IFNL3; the disease is chronic hepatitis C virus infection.