In accordance with these findings, another recent trial from Japan showed that the TT genotype of the rs8099917 polymorphism near the IL28B gene was associated with high LDL cholesterol levels, in addition to a high frequency of mutations in the interferon sensitivity-determining region and a wild type of core aa 70; this pattern was the most significant predictive factor of a lack of response to PEG-IFN-α/RBV in genotype 1b CHC patients with high viral loads [62]. The gene discussed is IFNL3; the disease is cryohydrocytosis.