In conclusion, our study provides the evidence that SZ-685C is a potent apoptosis inducer in breast cancer cells resistant to conventional ADR treatments in vitro as well as in vivo, and that such effects may be through suppressing Akt signaling, supporting the potential usefulness of combining SZ-685C with other therapeutic drugs in combating MDR in breast cancer chemotherapy. The gene discussed is AKT1; the disease is breast cancer.