PRKN and Tourette syndrome: Furthermore, there are important potential linkages between such genomic alterations and neurological development or neurodegeneration, for e.g. CNTNAP2 (2,3 Mb) localized within FRA7I at 7q35 found disrupted in a family with Gilles de la Tourette syndrome [38], and PARK2 (1.3 Mb) mutated in autosomal recessive juvenile Parkinson disease and located in the active center of FRA6E at 6q26 [39].