Some PLA2 enzymes may exacerbate Aβ cytotoxicity, as Aβ peptides stimulate cPLA2α activity in neuronal cultures [86] and primary cortical astrocytes [152]; in addition, Aβ-induced learning and memory deficits in a transgenic mouse model of AD are prevented by genetic ablation of cPLA2α activity in brain [152]. This evidence concerns the gene PLA2G6 and Alzheimer disease.