Recent research in a cohort investigating SLE has linked rs17884563 and rs740264 in the PON3 region [53] and five PON2 SNPs [52] (rs6954345, rs13306702, rs987539, rs11982486, and rs4729189) with PON1 POase activity [52, 53]. This evidence concerns the gene PON2 and systemic lupus erythematosus.