Interestingly, in a recent study it has been reported that in subjects with mesangial cell proliferation, as IgAN and diabetic nephropathy, there exists an increase of urinary adiponectin levels, which may partly result from enhanced filtration of circulating adiponectin through the changes of glomerular permselectivity and intraglomerular hydraulic pressure [32]. This evidence concerns the gene ADIPOQ and diabetic kidney disease.