AGT and hypertensive disorder: A new mechanism linking inflammation and high blood pressure mediated by Ang II was proposed by Marvar et al. Using mice subjected to a lesion in the anteroventral region of the third cerebral ventricle and infused with Ang II for 2 weeks, these authors observed a blunting of Ang II pressor effects, vascular oxidative stress, circulating T-lymphocyte activation, and their vascular infiltration [15].