Known tumor suppressor genes, e.g., CDKN2A (9p21.3), PTEN (10q23), and RB1 (13q14) were located within HD regions, as well as genes with potential tumor suppressor properties, e.g., CUL3 (2q36.2) and MGMT (10q26). The gene discussed is CDKN2A; the disease is neoplasm.