In addition, considering the relation between K8 point mutations and the predisposition to liver cirrhosis [19], and the link between cirrhosis and hepatocarcinogenesis [21], hepatic cells offer a model of choice to address the role of K8/K18 IFs as modulators of the mechanotransduction taking place during the cell tumorigenic process in simple epithelia. This evidence concerns the gene KRT8 and Cirrhosis.