Notably, maternal history of allergy/asthma intensified the observed SES trajectory effects (p value for interaction = 0.03, results not shown), such that especially high IL-6 responses were elicited by low-SES, overweight children with maternal allergy/asthma, while especially low responses were elicited by increasing-SES, normal weight children without maternal allergy/asthma. This evidence concerns the gene IL6 and allergic disease.