Both factors were recruited to the IFN-A1, A2 and IFN-A14 gene promoters following virus infection (Fig. 2); occupancy by IRF7 and IRF3 reached maximal values at 8–10 h; IRF7 enrichment of the promoters then decreased at 14 h p.i, concomitant with transcriptional inhibition, while significant recruitment of IRF3 was observed up to 16 h following infection. The gene discussed is IRF3; the disease is infection.